10 Pragmatic Free Trial That Are Unexpected
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Clinical trials that are designed to help inform practice in the real world are called pragmatic trials. They are usually focused on the practical aspects of research design, like the recruitment and consent process as well as adherence to the use of commonly available equipment.
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A pragmatic study that involves different investigators and participants from various geographical regions is the Home Blood Pressure Management study (HBPM). This kind of heterogeneity is necessary for pragmatic trials to be valid, and it also helps reduce the chance of bias in the results. A high degree of heterogeneity, however could cause issues with the design of the trial.
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Legality
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The purpose of pragmatic trials is to simulate real-life scenarios and gain maximum validity externally. They are typically commissioned by policymakers and practitioners in order to inform their decisions. They are also a good method of determining the causal relationship between an intervention and its outcomes. They should, however, not be used to replace explanatory studies.
The pragmatism concept is controversial and there are doubts about whether pragmatic trials should replace or complement them. Schwartz and Lellouch1 suggested the distinction between explanation studies, which support the validity of a physiological or clinical hypothesis, as well as pragmatic trials, that inform the decision-making process for policy and practice. They also suggested a framework dubbed PRECIS for pragmatic trials.2 The tool was designed to define the elements of a practical study, including recruitment, design, implementation of the intervention and follow-up.
There is a positive increase in the number of pragmatic trials published. A recent Medline search using the terms naturalistic and pragmatic, which was limited to controlled trials randomized to control (RCTs) produced 34 articles, shown in red in Figure 2. This is a sign that the health science community is becoming more acquaint to the issue of pragmatic thinking. It is important to keep in mind, however, that the majority were conducted in primary-care settings.